Predicting protein-protein interactions via multivariate mutual information of protein sequences
نویسندگان
چکیده
منابع مشابه
Predicting protein-protein interactions based only on sequences information.
Protein-protein interactions (PPIs) are central to most biological processes. Although efforts have been devoted to the development of methodology for predicting PPIs and protein interaction networks, the application of most existing methods is limited because they need information about protein homology or the interaction marks of the protein partners. In the present work, we propose a method ...
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In this study, a high accuracy protein-protein interaction prediction method is developed. The importance of the proposed method is that it only uses sequence information of proteins while predicting interaction. The method extracts phylogenetic profiles of proteins by using their sequence information. Combining the phylogenetic profiles of two proteins by checking existence of homologs in diff...
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Background: Protein-protein interactions do not provide any direct information regarding the domains within the proteins that mediate the interactions. The majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. Most of the former studies focus only on interacting domain pairs. However they do not consider the in...
متن کاملUsing Mutual Information Content of Protein Sequences for Classification
Protein sequence classification is a challenging problem. We are attempting to use the Mutual Information Content of protein sequences to provide an alternative method of classification. Since the 3D structure, and ultimately classification depends on the relationship between amino acids within a sequence, measuring the dependency of acids at different distances in a sequence may prove a valuab...
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MOTIVATION Despite advances in high-throughput methods for discovering protein-protein interactions, the interaction networks of even well-studied model organisms are sketchy at best, highlighting the continued need for computational methods to help direct experimentalists in the search for novel interactions. RESULTS We present a kernel method for predicting protein-protein interactions usin...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2016
ISSN: 1471-2105
DOI: 10.1186/s12859-016-1253-9